Arginine/Serine-rich Protein Interaction Domain-dependent Modulation of a Tau Exon 10 Splicing Enhancer
نویسندگان
چکیده
منابع مشابه
Expression, localization and tau exon 10 splicing activity of the brain RNA-binding protein TNRC4.
Elucidating the mechanisms of alternative splicing in the brain is a prerequisite to the understanding of the pathogenesis of major neurological diseases linked to impairment of pre-mRNA alternative splicing. The gene trinucleotide repeat-containing 4 (TNRC4) is predicted to encode a member of the CELF (CUG-BP- and ETR-3-like factors) family of RNA-binding proteins containing a 15-18-residue po...
متن کاملRegulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors.
Tau is a microtubule-associated protein whose transcript undergoes regulated splicing in the mammalian nervous system. Exon 10 of the gene is an alternatively spliced cassette that is adult-specific and encodes a microtubule-binding domain. Mutations increasing the inclusion of exon 10 result in the production of tau protein which predominantly contains four microtubule-binding repeats and were...
متن کاملCyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease.
Hyperphosphorylation and deposition of tau into neurofibrillary tangles is a hallmark of Alzheimer disease (AD). Alternative splicing of tau exon 10 generates tau isoforms containing three or four microtubule binding repeats (3R-tau and 4R-tau), which are equally expressed in adult human brain. Dysregulation of exon 10 causes neurofibrillary degeneration. Here, we report that cyclic AMP-depende...
متن کاملCyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer's disease
Jianhua Shi, Wei Qian, Xiaomin Yin, Khalid Iqbal, Inge Grundke-Iqbal, Xiaosong Gu, Fei Ding, Cheng-Xin Gong, and Fei Liu From Jiangsu Key Laboratory of Neuroregeneration and Department of Biochemistry, Medical School, Nantong University, Nantong, Jiangsu 226001, P. R. China; Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, N...
متن کاملSerine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers.
The 5' and 3' splice sites within an intron can, in principle, be joined to those within any other intron during pre-mRNA splicing. However, exons are joined in a strict 5' to 3' linear order in constitutively spliced pre-mRNAs. Thus, specific mechanisms must exist to prevent the random joining of exons. Here we report that insertion of exon sequences into an intron can inhibit splicing to the ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m505809200